Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
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Clozaril Product Description
Clozaril is an atypical antipsychotic agent, providing sedative, antipsychotic, antihistamine and anticholinergic effects. Clozaril is indicated to teenagers aged 18 years and above, adults and elderly patients for treatment of:
psychosis during the course of Parkinson's disease
suicidal behavior in patients with schizophrenia or schizoaffective disorder
Clozaril benefits are that the drug does not virtually cause any extrapyramidal side effects such as akathisia, dystonia, bradykinesia and tremor, like other antypsyshotics do.
In contrast to classic antipsychotics, Clozaril does not increase at all or insignificantly increases the level of prolactin. Because of this, such side effects as galactorrhea, gynaecomastia and amenorrhea are normally avoided during the antipsychotic treatment with Clozaril.
To treat mental disorders, a therapeutic dose of Clozaril is recommended to be adjusted individually. At the beginning of antipsychotic therapy, low doses of Clozaril are most effective ones. For the treatment of severe mental diseases, the maximum daily Clozaril dose of 900mg can be indicated. But Clozaril doses above 450mg may significantly increase the risk of seizures and other side effects.
Under no circumstances should the prescribed dose of Clozaril be increased or decreased. It is stricktly not recommended to interrupt Clozaril application for more than 2 days. If you’ve forgotten to take Clozaril tablets, take the missed dose of this antipsychotic drug as soon as you remember. However, if it is nearly the time for the next prescribed dose, do not take an extra antipsychotic pill to make up the missed dose of Clozaril.
Sudden cessation of the intake of the antypsyshotic drug may cause withdrawal symptom and adverse reactions. If treatment is required to be immediately terminated (for example, in case of developing eosinophilia), gradual reduction of Clozaril dose and careful observance for the patient's mental state are recommended. Patients 60 year old and above should start the antipsychotic treatment with very low doses of Clozaril, and gradually increase the daily dose, not more than by 25mg per day.
Store the Clozaril tablets in an original container to protect them from heat and moisture. Keep Clozaril out of the reach of children at temperature not above 30°C.
Clozaril Safety Information
During the treatment with Clozaril, severe neutropenia (abnormally low count of neutrophils) may develop in some patients, resulting in complex infection. High risk of neutropenia is observed in the first days of the antipsychotic therapy, and then is gradually decreased. Clozaril may increase the risk of seizures, so epileptic patients should take the antipsychotic with caution.
Information about psychotic diseases, contained in the review of Clozaril, is provided for the informational purposes only and should not be considered to substitute for qualified medical care or advice of the health care provider. The online pharmacy does not assume any liability or responsibility for damage, arising from any use of information on atypical antipsychotic agent Clozaril.
Clozaril Side Effects
Most adverse effects of Clozaril appear only at the beginning of the antipsychotic therapy and eventually disappear. The most frequent and serious adverse effects, which Clozaril may cause include: leukocytopenia, somnolence, dizziness and psychotic disorder. Other common adverse effects of antipsychotic agent Clozaril are reported as: granulopenia, seizure triggers, cardiovascular effects, fever drowsiness/sedation, dizziness, tachyarrhythmia, constipation and ptyalism.