Actonel, which is risedronate - is prescribed for treatment and prevention of osteoporosis (post-menopausal, caused by corticosteroids), Paget disease. Risedronate binds to substance of a bone tissue, inhibits its resorption mediated by osteoclasts and reduces a bone turn (does not break process of formation of a bone). It increases the biomechanical strength and volume of bone mass. The maximum decrease in a bone turn is observed in 3-6 months, remaining at the same level during a course of treatment.
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Actonel Product Description
Actonel is an anti-osteoporosis agent, which is indicated for the treatment of patients with fragile and brittle bones. Actonel should be used in one of the following conditions:
- Primary and secondary osteoporosis, including senile osteoporosis
- Deformation and violation of bone turnover (Paget's disease)
Bones become brittle due to increased transfer of minerals, including calcium, from the bone fluid into the circulatory system. Daily use of Actonel pills:
- Increases bone tissue metabolism
- Normalizes bone density and biochemical properties
- Inhibits the activity of the bone cells osteoclasts, destroying the hard part of the bone
For preventing or managing various types of osteoporosis, patients are advised taking one 5mg tablet per day, one 35mg tablet once in 7 days, or one 150 mg tablet in 30 days. To control Paget's disease, patients are prescribed one Actonel pill of 30 mg for a period of 8 weeks.
If the patient is prescribed taking Actonel daily, and omits the next dose, he/she should skip it. In all other cases, the missed dose should be taken on the following morning. If several doses of Actonel were missed several days in a row, patient may need the dosing schedule adjustment.
Food affects the bioavailability of Actonel, so doctors recommend taking the tablets on an empty stomach, at least half an hour before breakfast. In the middle of the day, Actonel should be taken between the meals. You should avoid lying down for a minimum of half an hour after the intake of this anti-osteoporosis agent.
No special storage conditions are required for Actonel drug. Recommended storage temperature for Actonel tablets is up to 25°C.
Actonel Safety Information
The anti-osteoporosis agent Actonel must be used with caution by people:
- Undergoing dental procedures
- Having complicated femoral shaft fractures
- With moderate or progressive stomach diseases
- Who are unable to maintain a vertical position for thirty minutes
This review on Actonel tablets is provided for informational purposes only, and is not intended to replace Actonel package insert, or the advice of a rheumatologist, orthopaedist or another doctor, specializing in the treatment of metabolic bone diseases.
The online pharmacy shall not be liable to you for any damages, caused by use of any information on the antiresorptive agent Actonel, including any kind of information about the osteoporosis treatment, which may be incomplete or outdated.
Actonel Side Effects
Possible undesirable effects of Actonel are expressed mildly or moderately, and do not require discontinuation of osteoporosis treatment. Possible symptoms, resulting from the treatment with Actonel tablets, may depend on the patient's sex.
In women with postmenopausal osteoporosis, Actonel may cause: abdominal pain, diarrhea, dyspepsia, back pain, arthralgia, myalgia, and bone pain. In men, using Actonel fot the improvement of the bone mineral density, hypesthesia, arrhythmia or adenofibromatous hyperplasia may develop, as well as the undesirable effects that are frequently observed in women.
Postmarketing experience show that some men and women are showing signs of hypersensitivity and symptoms of serious skin reactions (incl. generalized rash and Lyell's syndrome), when they use Actonel pills. Less frequently, Actonel causes eye inflammation or pain of varying intensity and localization.