Cefadroxil - cephalosporin antibiotic of the I generation for intake. It works as bactericidal, breaking synthesis of a cell wall of microorganisms. It has a broad spectrum of activity: it is active in relation as gram-positive (Staphylococcus spp. which don't produce and produce a penicillinase; Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis), and gram-negative microorganisms (Shigella spp., Salmonella spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., some strains of Proteus spp., especially Proteus mirabilis), Moraxella catarrhalis (Branhamella). Many strains of Enterococcus faecalis and Enterococcus faecium are steady against Cefadroxil.
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Cefadroxil product description
Cefadroxil is a semi-synthetic antibiotic of the cephalosporin series. It has a bactericidal effect. The mechanism of action of Cefadroxil is connected with a violation of the synthesis of components of the membrane of bacterial cells.
Infections caused by microorganisms susceptible to Cefadroxil, namely: chronic otitis media and sinusitis; pharyngitis tonsillitis diseases of the lower respiratory tract (acute and chronic bronchitis, pneumonia), urinary tract viruses (complicated and uncomplicated); skin and soft tissue diseases, viruses of the bones and joints.
Cefadroxil safety information
Medicine is contraindicated in such cases:
- Hypersensitivity to cephalosporins. That is a possible cross-allergy potential, with strong sensitivity to penicillin.
- In speak about the therapy of nursing mothers, they mustn’t use breastfeeding. It can be started in 2 days after the end of medication.
Features of the overdose of the remedy: nausea, hallucinations, hyperreflexia, extrapyramidal disorders, confusion, coma, renal dysfunction.
First actions after taking a toxic dose must be gastric lavage, hemodialysis if it is needed. In addition, the specialist has to make a monitoring, if necessary correction of water-electrolyte status, monitoring of kidney function.
The time between the intaking of Cefadroxil need to be increased in persons with existing renal insufficiency with prolonged use of Cefadroxil, the blood composition and functional status of the liver and kidneys have to be monitored. When allergic reactions and diarrhea occur, a course of remedy with Cefadroxil should be stopped. If you suspect pseudomembranous colitis caused by taking antibiotics, you should start therapy with vancomycin. Anti-peristaltic substances are contraindicated too.
A prolonged course of therapy can include hypovitaminosis K (hemorrhage), hypovitaminosis B (stomatitis, glossitis, neuritis, anorexia, etc.) and a false-positive direct Crumbs test: it should be borne in mind that positive results of the Coombs test are related to the use of Cefadroxil. This also applies to newborns whose mothers were treated with cephalosporins before childbirth.
Interaction with other medicinal products
The use of Cefadroxil in combination with aminoglycoside antibiotics, polymyxin B, whey or high doses of diuretics that affect reabsorption in the Henle loop is not desirable since such a combination contributes to the potentiation of the nephrotoxic effect. The risk of hemorrhagic complications enlarges with prolonged use of anticoagulants or platelet aggregation inhibitors, Cefadroxil may reduce the effectiveness of oral contraceptives.
Cefadroxil side effects
Often side conditions are observed from the gastrointestinal tract (nausea, vomiting, diarrhea, abdominal pain), occasionally allergic rashes on the skin, itching, rarely occur glossitis, dizziness, insomnia, anaphylactic shock. In some cases, there is an increase in opportunistic microorganisms (fungi), which can lead to vaginal mycoses, candidiasis stomatitis, etc.