Gyne-Lotrimin - antifungal medicine from group of derivatives of imidazole for external and local (intravaginal) use, reduces synthesis of ergosterol which is a component of a cellular membrane of a microbic wall and leads to change of its structure and properties.
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Gyne-Lotrimin product description
An Antifungal agent from the group of imidazole derivatives for external and local (intravaginal) use. It reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall and leads to a change in its structure and properties.In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum Canis), yeast and mold fungi (genus Candida, Torulopsis glabrata, genus Rhodotorula, Malassezia furfur), causative agents of colored lichen, erythrasma, gram-positive (Staphylococcus, Streptococcus, Corynebacterium minutissimum) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), Trichomonas vaginalis.
It is used for fungal lesions of the skin and mucous membranes, such as dermatomycosis, dermatophytosis, trichophytosis, epidermophytia, microsporia, candidamycosis, stomatitis, interdigital fungal erosion, fungal paronychia; mycoses complicated by secondary pyoderma; Candidiasis vulvitis, vulvovaginitis, balanitis, trichomoniasis; pityriasis lichen, multicolored lichen, erythrasma; sanation of the birth canal before delivery.
In candidiasis vulvitis and candidal balanitis in adults, a strip of cream is applied to a thin layer on the affected areas and rubbed. The therapy of these diseases requires simultaneous treatment of both partners.
With the simultaneous application of a cream with latex products (such as condoms and diaphragms), the functional capacity of the latter may decrease. Patients are advised to use alternative contraceptive methods for at least 5 days after consumption of the drug.
Gyne-Lotrimin safety information
It is not recommended to apply the cream to the areas of the skin near the eyes. Avoid contact with eyes. Do not swallow the cream. It is recommended to treat all affected skin at the same time.
It causes changes in the fungal wall, inhibits the synthesis of sterols by bacteria, trichomonads and leads to their death. The cream is not contraindicated in the II and III trimesters of pregnancy (there is no data on an application in the I-th trimester).
There is no risk of acute intoxication because it is unlikely that overdose is possible after application to the skin (application to large areas of the skin under conditions conducive to increased absorption), as well as after accidental oral administration. No specific antidote exists. In case of accidental oral administration, it may rarely be necessary to have a stomach flush. In case of a medical care with a help of this product, you should stop breastfeeding. The Gyne-Lotrimin cream should not be applied to the mammary glands while breastfeeding.
Gyne-Lotrimin side effects
Among the contraindications, there is hypersensitivity to the active component or to other components of the cream. The cream should not be used to treat nails or skin scalp infections. In case of neglecting the rules of using the cream, the risk of development of side reactions occurrence grows. Among such reactions, there may be allergic reactions, including urticaria, dyspnea, arterial hypotension, syncope, increases; itching, rash, blistering, skin exfoliation, discomfort/pain, edema, redness (erythema), burning sensation, feeling of heat, irritation.