The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
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The tablets are aimed at normalizing blood plasma composition. They reduce triglyceride content and increase apolipoprotein AI. The medicine inhibits peripheral lipolysis, helps to remove free fatty acids from the liver and blocks the inclusion of acyl in synthesized triglycerides. They lower its levels in the liver.
The pills make faster turnover and removal of cholesterol and promote its excretion from the body. The components of the remedy are well absorbed if you take it inside. Absorption occurs one and a half hours after administration. The tablets are low-toxic and they make a concentration of lipids in the blood lower. They decrease lipoprotein in patients with hypertriglyceridemia and increase the number of triglycerides in the blood.
The drug does not react to the treatment by diet or other hypolipidemic agents. It increases the concentration of HDL (high-density lipoproteins).The medicine is prescribed for patients with hypertriglyceridemia if they are resistant to a therapeutic diet or other related means. If one has hyperchylomicronemia (increased blood levels of chylomicrons /neutral fat particles with a diameter of 1 micron due to family deficiency of lipoprotein lipase (an enzyme that destroys lipoproteins), the drug will be ineffective.
It is necessary to check the number of lipids in the blood during the treatment. If the effectiveness of the drugs is not manifested within three months, then the therapy should be stopped. It is also necessary to follow the diet. In long-term care one needs a constant control of the peripheral blood and as well as of indications of the functions of the liver. If there are significant changes in the liver, it is necessary to stop treatment until the normal findings.
If you miss a dose of pills you need to take the next one as soon as possible and double it twice. Sometimes the pain in the muscles may appear and in this case, it is necessary to exclude the presence of myositis. If it is found in the body, the treatment will be canceled. One should stop taking pills if cholelithiasis is detected. The tablets are incompatible with lovastatin because there may be a severe form of myopathy or liver failure. The drug enhances the effect of indirect anticoagulants and oral hypoglycemic drugs.
While taking the drugs, the risk of violations of fat metabolism increases. Adult patients have prescribed pills of 0.45 grams twice a day. It is usually taken in the morning 30 minutes before breakfast or in the evening and 30 minutes before dinner. The highest therapeutic effect is observed after three or four weeks after the first administration of the tablet.
The medicine has an adverse reaction on the nervous system. One may feel the following symptoms:
- a headache;
- excessive fatigue;
Sometimes there is dysfunction in the digestive system, such as dry mouth, low appetite, nausea, vomiting, heartburn, constipation or diarrhea. On the part of the human motor system can there are:
- Myasthenia gravis;
In the genitourinary system, there are decreases in potency and libido. Sometimes there are allergic reactions that appear in the skin, for example, rash or dermatitis. Among other sideway actions, one can identify visual impairment, hypokalemia, alopecia, synovitis.